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Oct 21

Synthetic Generation and Latent Projection Denoising of Rim Lesions in Multiple Sclerosis

Quantitative susceptibility maps from magnetic resonance images can provide both prognostic and diagnostic information in multiple sclerosis, a neurodegenerative disease characterized by the formation of lesions in white matter brain tissue. In particular, susceptibility maps provide adequate contrast to distinguish between "rim" lesions, surrounded by deposited paramagnetic iron, and "non-rim" lesion types. These paramagnetic rim lesions (PRLs) are an emerging biomarker in multiple sclerosis. Much effort has been devoted to both detection and segmentation of such lesions to monitor longitudinal change. As paramagnetic rim lesions are rare, addressing this problem requires confronting the class imbalance between rim and non-rim lesions. We produce synthetic quantitative susceptibility maps of paramagnetic rim lesions and show that inclusion of such synthetic data improves classifier performance and provide a multi-channel extension to generate accompanying contrasts and probabilistic segmentation maps. We exploit the projection capability of our trained generative network to demonstrate a novel denoising approach that allows us to train on ambiguous rim cases and substantially increase the minority class. We show that both synthetic lesion synthesis and our proposed rim lesion label denoising method best approximate the unseen rim lesion distribution and improve detection in a clinically interpretable manner. We release our code and generated data at https://github.com/agr78/PRLx-GAN upon publication.

  • 9 authors
·
May 29, 2025

Quarks to Cosmos: Particles and Plasma in Cosmological evolution

We describe in the context of the particle physics (PP) standard model (SM) `PP-SM' the understanding of the primordial properties and composition of the Universe in the temperature range 130GeV>T>20keV. The Universe evolution is described using FLRW cosmology. We present a global view on particle content across time and describe the different evolution eras using deceleration parameter q. We follow the arrow of time in the expanding and cooling Universe: After the PP-SM heavies (t, h, W, Z) diminish in abundance below Tsimeq 50GeV, the PP-SM plasma in the Universe is governed by the strongly interacting Quark-Gluon content. Once the temperature drops below Tsimeq 150MeV, quarks and gluons hadronize into strongly interacting matter particles. Rapid disappearance of baryonic antimatter completes at T_B=38.2MeV. We study the ensuing disappearance of strangeness and mesons in general. We show that the different eras defined by particle populations are barely separated from each other with abundance of muons fading out just prior to T=O(2.5)MeV, the era of emergence of the free-streaming neutrinos. We discuss the two relevant fundamental constants controlling the decoupling of neutrinos. We subsequently follow the primordial Universe as it passes through the hot dense electron-positron plasma epoch. The high density of positron antimatter disappears near T=20.3keV: Nuclear reactions occur in the presence of a highly mobile and relatively strongly interacting electron-positron plasma phase. We apply plasma theory methods to describe the strong screening effects between heavy dust particle (nucleons). We analyze the paramagnetic characteristics of the electron-positron plasma when exposed to an external primordial magnetic field.

  • 5 authors
·
Sep 26, 2024

Competition of Exchange and Correlation Energies in Two-Dimensional $N$-component Electron Gas Ferromagnetism

Motivated by recent observations of symmtry broken phases in lightly-doped multilayer graphene, we investigate magnetic phase transitions in a generalized electron gas model with four-component electron spin. This model simplifies the problem with a parabolic dispersion band, abstracting away the details of the graphene band structure to focus solely on the effects of the Coulomb interaction. We report four findings: 1) In the Hartree-Fock approximation, we observe that the paramagnetic state undergoes a sequence of density-driven, first-order phase transitions, progressively depopulating electrons from each spin component until achieving complete polarization within a very narrow density window where 1.2<r_s<2 (r_s being the electron gas parameter). 2) Further incorporating the correlation energy via the Bohm-Pines random-phase approximation shows that the cascade of transitions obtained within Hartree-Fock approximation is replaced by a single ferromagnetic phase transition at r_s = 6.12. 3) The disappearance of cascade is due to the correlation energy difference between the four-component paramagnetic state and symmetry-broken phases, which is nearly an order of magnitude more negative than the corresponding Hartree-Fock energy difference for 1.2 < r_s < 2. 4) The transition from the paramagnetic state to the fully polarized state at r_s=6.12 is governed by the balance between exchange and correlation energies, a competition that cannot be captured by mean-field approximations to models featuring effective (density-dependent) delta-function interactions, such as the Stoner model. We use the insights from our model to comment on the phase diagram of multilayer graphene electron gas.

  • 3 authors
·
Jul 1, 2024

Complex Magnetic Phases and Unconventional Skyrmion Thermodynamics in Magnetically Intercalated Cr$_{1+x}$Te$_2$Compounds

Chemical intercalation provides a powerful route for tuning the electronic and magnetic properties of transition metal dichalcogenides (TMDs), enabling the emergence of magnetic phases and phenomena that are otherwise inaccessible in their pristine forms. Here, we investigate the structural, electronic, and magnetic properties of magnetically intercalated Cr_{1+x}Te_2 through a combination of scanning tunneling microscopy, angle-resolved photoemission spectroscopy, magnetization, electrical transport, and Lorentz transmission electron microscopy measurements. We uncover a rich magnetic phase diagram comprising paramagnetic, in-plane spin-fluctuation, out-of-plane ferromagnetic, and field-induced Néel-type skyrmion phases. In particular, Lorentz transmission electron microscopy directly reveals the formation of Néel-type skyrmion textures slightly below the Curie temperature, with their configurations evolving strongly with temperature and magnetic field. The skyrmions exhibit pronounced thermal hysteresis and coexist with stripe domains, indicative of a complex magnetic energy landscape arising from the competition among disorder-induced local Dzyaloshinskii-Moriya interactions, perpendicular magnetic anisotropy, and dipolar interactions. Our results demonstrate that chemical intercalation can profoundly reshape the magnetic interactions and phase behavior of TMDs, establishing Cr_{1+x}Te_2 as a versatile platform for exploring tunable magnetism, skyrmion physics, and unconventional thermodynamic phenomena in low-dimensional quantum materials.

  • 16 authors
·
Sep 30

Markov length can diverge in systems whose universal physics is spatially Markovian

Conditional mutual information (CMI) probes spatial non-Markovianity and plays a central role in a recently developed framework for defining mixed-state phases based on local reversibility. This framework sharply distinguishes exponentially decaying from algebraically decaying CMI, since the latter obstructs equivalence to a state with finite Markov length. Here we show that states that flow to the same renormalization-group (RG) fixed point can nevertheless exhibit qualitatively different CMI. Starting from a critical Gibbs state of a finite-range local classical Hamiltonian, whose CMI vanishes beyond the interaction range, we show that an RG-irrelevant perturbation that breaks detailed balance generically generates algebraically decaying CMI. Crucially, these power-law tails are cutoff-suppressed: although they lead to an infinite Markov length at every fixed lattice cutoff, they vanish as a positive power of the cutoff in the continuum limit. We construct solvable models that exhibit this phenomenon and predict that the Ising-symmetric critical point of Toom's cellular automata generically exhibits such behavior. We also find analogous cutoff-suppressed CMI in the high-temperature paramagnetic phase of the long-range Ising paramagnet, in contrast with the genuine power-law CMI at the finite-temperature critical point in this same model that survives the continuum limit. We also derive a general result that in one spatial dimension, CMI decays faster than the inverse square of the buffer length if and only if the long-distance physics is Markovian.

  • 2 authors
·
Oct 7

High-throughput calculations of magnetic topological materials

The discoveries of intrinsically magnetic topological materials, including semimetals with a large anomalous Hall effect and axion insulators, have directed fundamental research in solid-state materials. Topological quantum chemistry has enabled the understanding of and the search for paramagnetic topological materials. Using magnetic topological indices obtained from magnetic topological quantum chemistry (MTQC), here we perform a high-throughput search for magnetic topological materials based on first-principles calculations. We use as our starting point the Magnetic Materials Database on the Bilbao Crystallographic Server, which contains more than 549 magnetic compounds with magnetic structures deduced from neutron-scattering experiments, and identify 130 enforced semimetals (for which the band crossings are implied by symmetry eigenvalues), and topological insulators. For each compound, we perform complete electronic structure calculations, which include complete topological phase diagrams using different values of the Hubbard potential. Using a custom code to find the magnetic co-representations of all bands in all magnetic space groups, we generate data to be fed into the algorithm of MTQC to determine the topology of each magnetic material. Several of these materials display previously unknown topological phases, including symmetry-indicated magnetic semimetals, three-dimensional anomalous Hall insulators and higher-order magnetic semimetals. We analyse topological trends in the materials under varying interactions: 60 per cent of the 130 topological materials have topologies sensitive to interactions, and the others have stable topologies under varying interactions. We provide a materials database for future experimental studies and open-source code for diagnosing topologies of magnetic materials.

  • 9 authors
·
Feb 28, 2020

Pairing-channel reconstruction by Ising spin-orbit coupling in a multiorbital triangular-lattice model

Ising spin-orbit coupling (SOC) is widely known for locking electronic spins and protecting superconductivity against in-plane paramagnetic pair breaking. Here we show that, in a correlated multiorbital system, Ising SOC can play a qualitatively different role: it reconstructs the hierarchy of spin-fluctuation-mediated pairing channels by reshaping the low-energy Fermi surfaces, orbital-spin coherence factors, and momentum-resolved scattering phase space. We study a noncentrosymmetric two-orbital triangular-lattice model with Rashba SOC, Ising SOC, and onsite SOC. We solve the pairing problem within a multiorbital random-phase-approximation framework. In the single-orbital limit, an E-representation state with a dominant S_z=0 component emerges only at relatively strong Ising SOC. Orbital degrees of freedom facilitate the stabilization of this pairing state at a smaller nominal Ising SOC strength and generate a broad competition between E and A_1 pairing channels. The E state can maintain the same S_z=0 triplet character, whereas the A_1 state becomes a fully gapped sign-changing splusminus superconductor. The latter also realizes a topologically nontrivial phase in the time-reversal-invariant weak-pairing regime, with a nonzero Z_2 index, Wilson-loop spectral flow, and boundary modes. Its topology is not carried by a single orbital pairing component, but emerges cooperatively from the dominant intra- and inter-orbital pairing components. These results establish a microscopic route by which Ising SOC and orbital hybridization can reconstruct interaction-driven superconductivity, producing both Ising-triplet and topological singlet-dominated phases in correlated non-centrosymmetric systems.

  • 5 authors
·
Oct 14