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Oct 8

When to Think Fast and Slow? AMOR: Adaptive Entropy Gate for Hybrid Models

Recurrent-attention hybrids aim to combine the efficiency of recurrence with the expressivity of attention, but existing approaches typically apply attention uniformly across all positions, even when the recurrent state alone is sufficient for accurate prediction. We introduce AMOR (Adaptive Metacognitive Output Router), a post-hoc hybrid architecture that selectively invokes attention based on predictive uncertainty. A recurrent backbone is augmented with entropy-gated attention blocks that activate only when the model's output entropy exceeds a dynamic threshold derived from a running batch median and scaled standard deviation. This yields a simple, gradient-free routing mechanism inspired by uncertainty-driven computation and the System 1 / System 2 distinction. Across Mamba2 and Gated DeltaNet backbones (180M-1.5B), AMOR consistently matches or outperforms both pure recurrent models and fixed-schedule hybrid baselines while invoking attention on only ~22% of tokens. It achieves strong performance on common-sense reasoning benchmarks and maintains stable long-context performance on LongBench, where prior hybrid models degrade under distribution shift. These results suggest that when attention is applied matters as much as how much: selectively allocating attention based on predictive uncertainty improves both efficiency and robustness, offering a simple alternative to uniform or fixed routing strategies and pointing toward adaptive hybrid architectures that dynamically match computation to input difficulty.

  • 2 authors
·
May 12

ContestTrade: A Multi-Agent Trading System Based on Internal Contest Mechanism

In financial trading, large language model (LLM)-based agents demonstrate significant potential. However, the high sensitivity to market noise undermines the performance of LLM-based trading systems. To address this limitation, we propose a novel multi-agent system featuring an internal competitive mechanism inspired by modern corporate management structures. The system consists of two specialized teams: (1) Data Team - responsible for processing and condensing massive market data into diversified text factors, ensuring they fit the model's constrained context. (2) Research Team - tasked with making parallelized multipath trading decisions based on deep research methods. The core innovation lies in implementing a real-time evaluation and ranking mechanism within each team, driven by authentic market feedback. Each agent's performance undergoes continuous scoring and ranking, with only outputs from top-performing agents being adopted. The design enables the system to adaptively adjust to dynamic environment, enhances robustness against market noise and ultimately delivers superior trading performance. Experimental results demonstrate that our proposed system significantly outperforms prevailing multi-agent systems and traditional quantitative investment methods across diverse evaluation metrics. ContestTrade is open-sourced on GitHub at https://github.com/FinStep-AI/ContestTrade.

  • 9 authors
·
Aug 1, 2025

DAS: Dual-Aligned Semantic IDs Empowered Industrial Recommender System

Semantic IDs are discrete identifiers generated by quantizing the Multi-modal Large Language Models (MLLMs) embeddings, enabling efficient multi-modal content integration in recommendation systems. However, their lack of collaborative signals results in a misalignment with downstream discriminative and generative recommendation objectives. Recent studies have introduced various alignment mechanisms to address this problem, but their two-stage framework design still leads to two main limitations: (1) inevitable information loss during alignment, and (2) inflexibility in applying adaptive alignment strategies, consequently constraining the mutual information maximization during the alignment process. To address these limitations, we propose a novel and flexible one-stage Dual-Aligned Semantic IDs (DAS) method that simultaneously optimizes quantization and alignment, preserving semantic integrity and alignment quality while avoiding the information loss typically associated with two-stage methods. Meanwhile, DAS achieves more efficient alignment between the semantic IDs and collaborative signals, with the following two innovative and effective approaches: (1) Multi-view Constrative Alignment: To maximize mutual information between semantic IDs and collaborative signals, we first incorporate an ID-based CF debias module, and then design three effective contrastive alignment methods: dual user-to-item (u2i), dual item-to-item/user-to-user (i2i/u2u), and dual co-occurrence item-to-item/user-to-user (i2i/u2u). (2) Dual Learning: By aligning the dual quantizations of users and ads, the constructed semantic IDs for users and ads achieve stronger alignment. Finally, we conduct extensive offline experiments and online A/B tests to evaluate DAS's effectiveness, which is now successfully deployed across various advertising scenarios at Kuaishou App, serving over 400 million users daily.

  • 6 authors
·
Aug 14, 2025

Step-3 is Large yet Affordable: Model-system Co-design for Cost-effective Decoding

Large language models (LLMs) face low hardware efficiency during decoding, especially for long-context reasoning tasks. This paper introduces Step-3, a 321B-parameter VLM with hardware-aware model-system co-design optimized for minimizing decoding costs. Step-3 innovates in two key dimensions: (1) A novel Multi-Matrix Factorization Attention (MFA) mechanism that significantly reduces both KV cache size and computation while maintaining high attention expressiveness, and (2) Attention-FFN Disaggregation (AFD), a distributed inference system that decouples attention and Feed-Forward Network (FFN) layers into specialized subsystems. This co-design achieves unprecedented cost efficiency: Step-3 significantly reduces theoretical decoding costs compared with models like DeepSeek-V3 and Qwen3 MoE 235B, with the gains widening at longer context. Step-3 achieves low cost while activating 38B parameters per token (more than DeepSeek-V3 and Qwen3 MoE 235B), demonstrating that hardware-aligned attention arithmetic intensity, MoE sparsity, and AFD are critical to cost-effectiveness. We perform a head-to-head comparison with DeepSeek-V3 in its favorable scenarios. Our implementation on Hopper GPUs achieves a decoding throughput of up to 4,039 tokens per second per GPU under 50ms TPOT SLA (4K context, FP8, no MTP). It is higher than DeepSeek-V3's 2,324 in the same setup and sets a new Pareto frontier for LLM decoding.

  • 199 authors
·
Jul 25, 2025 2

Hierarchical Auto-Organizing System for Open-Ended Multi-Agent Navigation

Due to the dynamic and unpredictable open-world setting, navigating complex environments in Minecraft poses significant challenges for multi-agent systems. Agents must interact with the environment and coordinate their actions with other agents to achieve common objectives. However, traditional approaches often struggle to efficiently manage inter-agent communication and task distribution, crucial for effective multi-agent navigation. Furthermore, processing and integrating multi-modal information (such as visual, textual, and auditory data) is essential for agents to comprehend their goals and navigate the environment successfully and fully. To address this issue, we design the HAS framework to auto-organize groups of LLM-based agents to complete navigation tasks. In our approach, we devise a hierarchical auto-organizing navigation system, which is characterized by 1) a hierarchical system for multi-agent organization, ensuring centralized planning and decentralized execution; 2) an auto-organizing and intra-communication mechanism, enabling dynamic group adjustment under subtasks; 3) a multi-modal information platform, facilitating multi-modal perception to perform the three navigation tasks with one system. To assess organizational behavior, we design a series of navigation tasks in the Minecraft environment, which includes searching and exploring. We aim to develop embodied organizations that push the boundaries of embodied AI, moving it towards a more human-like organizational structure.

  • 7 authors
·
Mar 13, 2024

HOBBIT: A Mixed Precision Expert Offloading System for Fast MoE Inference

The Mixture-of-Experts (MoE) architecture has demonstrated significant advantages in the era of Large Language Models (LLMs), offering enhanced capabilities with reduced inference costs. However, deploying MoE-based LLMs on memoryconstrained edge devices remains challenging due to their substantial memory requirements. While existing expertoffloading methods alleviate the memory requirements, they often incur significant expert-loading costs or compromise model accuracy. We present HOBBIT, a mixed precision expert offloading system to enable flexible and efficient MoE inference. Our key insight is that dynamically replacing less critical cache-miss experts with low precision versions can substantially reduce expert-loading latency while preserving model accuracy. HOBBIT introduces three innovative techniques that map the natural hierarchy of MoE computation: (1) a token-level dynamic expert loading mechanism, (2) a layer-level adaptive expert prefetching technique, and (3) a sequence-level multidimensional expert caching policy. These innovations fully leverage the benefits of mixedprecision expert inference. By implementing HOBBIT on top of the renowned LLM inference framework Llama.cpp, we evaluate its performance across different edge devices with representative MoE models. The results demonstrate that HOBBIT achieves up to a 9.93x speedup in decoding compared to state-of-the-art MoE offloading systems.

  • 8 authors
·
Nov 3, 2024

VideoAgent2: Enhancing the LLM-Based Agent System for Long-Form Video Understanding by Uncertainty-Aware CoT

Long video understanding has emerged as an increasingly important yet challenging task in computer vision. Agent-based approaches are gaining popularity for processing long videos, as they can handle extended sequences and integrate various tools to capture fine-grained information. However, existing methods still face several challenges: (1) they often rely solely on the reasoning ability of large language models (LLMs) without dedicated mechanisms to enhance reasoning in long video scenarios; and (2) they remain vulnerable to errors or noise from external tools. To address these issues, we propose a specialized chain-of-thought (CoT) process tailored for long video analysis. Our proposed CoT with plan-adjust mode enables the LLM to incrementally plan and adapt its information-gathering strategy. We further incorporate heuristic uncertainty estimation of both the LLM and external tools to guide the CoT process. This allows the LLM to assess the reliability of newly collected information, refine its collection strategy, and make more robust decisions when synthesizing final answers. Empirical experiments show that our uncertainty-aware CoT effectively mitigates noise from external tools, leading to more reliable outputs. We implement our approach in a system called VideoAgent2, which also includes additional modules such as general context acquisition and specialized tool design. Evaluation on three dedicated long video benchmarks (and their subsets) demonstrates that VideoAgent2 outperforms the previous state-of-the-art agent-based method, VideoAgent, by an average of 13.1% and achieves leading performance among all zero-shot approaches

  • 7 authors
·
Apr 6, 2025

Mandol: An Agglomerative Agent Memory System for Long-Term Conversations

Long-term conversational agents need to remember and query cross-session, multi-typed information with complex correlations. Existing agent memory systems rely on heterogeneous vector and graph databases, which fragment memory information and cause high cross-database I/O latency. For retrieval, common RAG-style methods tend to introduce noise, miss correlated clues, and lack token budget control, degrading LLM accuracy and efficiency. We propose Mandol, an agglomerative memory system that consolidates fragmented memory representations and storage into a unified memory-native architecture. Its core components include: (1) a hierarchical memory model that organizes memory into a basic layer representing raw memory information and a high-level abstract layer that agglomerates basic memories into traceable abstract memories, both uniformly represented as structured semantic graphs; (2) an agglomerative semantic data structure combining SemanticMap and SemanticGraph, which natively fuses key-value, vector, and graph structures and provides unified hybrid retrieval operators to eliminate cross-database I/O; and (3) a quantitative query mechanism with query-adaptive routing, quantitative denoising and conflict resolution, and token-constrained context generation, all without involving LLMs during retrieval. Experiments on two widely used long-term conversation benchmarks, LoCoMo and LongMemEval, show that Mandol achieves the best overall accuracy among representative agent memory systems. For performance comparison, Mandol also obtains a 5.4x retrieval speedup and a 4.8x insertion speedup under 10 QPS concurrent load, while still maintaining low latency on consumer-grade hardware.

  • 6 authors
·
Jun 28

"Take Me Home, Wi-Fi Drone": A Drone-based Wireless System for Wilderness Search and Rescue

Wilderness Search and Rescue (WiSAR) represents a longstanding and critical societal challenge, demanding innovative and automatic technological solutions. In this paper, we introduce Wi2SAR, a novel autonomous drone-based wireless system for long-range, through-occlusion WiSAR operations, without relying on existing infrastructure. Our basic insight is to leverage the automatic reconnection behavior of modern Wi-Fi devices to known networks. By mimicking these networks via on-drone Wi-Fi, Wi2SAR uniquely facilitates the discovery and localization of victims through their accompanying mobile devices. Translating this simple idea into a practical system poses substantial technical challenges. Wi2SAR overcomes these challenges via three distinct innovations: (1) a rapid and energy-efficient device discovery mechanism to discover and identify the target victim, (2) a novel RSS-only, long-range direction finding approach using a 3D-printed Luneburg Lens, amplifying the directional signal strength differences and significantly extending the operational range, and (3) an adaptive drone navigation scheme that guides the drone toward the target efficiently. We implement an end-to-end prototype and evaluate Wi2SAR across various mobile devices and real-world wilderness scenarios. Experimental results demonstrate Wi2SAR's high performance, efficiency, and practicality, highlighting its potential to advance autonomous WiSAR solutions. Wi2SAR is open-sourced at https://aiot-lab.github.io/Wi2SAR to facilitate further research and real-world deployment.

  • 3 authors
·
Apr 9

FASIONAD++ : Integrating High-Level Instruction and Information Bottleneck in FAt-Slow fusION Systems for Enhanced Safety in Autonomous Driving with Adaptive Feedback

Ensuring safe, comfortable, and efficient planning is crucial for autonomous driving systems. While end-to-end models trained on large datasets perform well in standard driving scenarios, they struggle with complex low-frequency events. Recent Large Language Models (LLMs) and Vision Language Models (VLMs) advancements offer enhanced reasoning but suffer from computational inefficiency. Inspired by the dual-process cognitive model "Thinking, Fast and Slow", we propose FASIONAD -- a novel dual-system framework that synergizes a fast end-to-end planner with a VLM-based reasoning module. The fast system leverages end-to-end learning to achieve real-time trajectory generation in common scenarios, while the slow system activates through uncertainty estimation to perform contextual analysis and complex scenario resolution. Our architecture introduces three key innovations: (1) A dynamic switching mechanism enabling slow system intervention based on real-time uncertainty assessment; (2) An information bottleneck with high-level plan feedback that optimizes the slow system's guidance capability; (3) A bidirectional knowledge exchange where visual prompts enhance the slow system's reasoning while its feedback refines the fast planner's decision-making. To strengthen VLM reasoning, we develop a question-answering mechanism coupled with reward-instruct training strategy. In open-loop experiments, FASIONAD achieves a 6.7% reduction in average L2 trajectory error and 28.1% lower collision rate.

  • 19 authors
·
Mar 11, 2025

BTL-UI: Blink-Think-Link Reasoning Model for GUI Agent

In the field of AI-driven human-GUI interaction automation, while rapid advances in multimodal large language models and reinforcement fine-tuning techniques have yielded remarkable progress, a fundamental challenge persists: their interaction logic significantly deviates from natural human-GUI communication patterns. To fill this gap, we propose "Blink-Think-Link" (BTL), a brain-inspired framework for human-GUI interaction that mimics the human cognitive process between users and graphical interfaces. The system decomposes interactions into three biologically plausible phases: (1) Blink - rapid detection and attention to relevant screen areas, analogous to saccadic eye movements; (2) Think - higher-level reasoning and decision-making, mirroring cognitive planning; and (3) Link - generation of executable commands for precise motor control, emulating human action selection mechanisms. Additionally, we introduce two key technical innovations for the BTL framework: (1) Blink Data Generation - an automated annotation pipeline specifically optimized for blink data, and (2) BTL Reward -- the first rule-based reward mechanism that enables reinforcement learning driven by both process and outcome. Building upon this framework, we develop a GUI agent model named BTL-UI, which demonstrates consistent state-of-the-art performance across both static GUI understanding and dynamic interaction tasks in comprehensive benchmarks. These results provide conclusive empirical validation of the framework's efficacy in developing advanced GUI Agents.

  • 11 authors
·
Sep 19, 2025 3

PerfGuard: A Performance-Aware Agent for Visual Content Generation

The advancement of Large Language Model (LLM)-powered agents has enabled automated task processing through reasoning and tool invocation capabilities. However, existing frameworks often operate under the idealized assumption that tool executions are invariably successful, relying solely on textual descriptions that fail to distinguish precise performance boundaries and cannot adapt to iterative tool updates. This gap introduces uncertainty in planning and execution, particularly in domains like visual content generation (AIGC), where nuanced tool performance significantly impacts outcomes. To address this, we propose PerfGuard, a performance-aware agent framework for visual content generation that systematically models tool performance boundaries and integrates them into task planning and scheduling. Our framework introduces three core mechanisms: (1) Performance-Aware Selection Modeling (PASM), which replaces generic tool descriptions with a multi-dimensional scoring system based on fine-grained performance evaluations; (2) Adaptive Preference Update (APU), which dynamically optimizes tool selection by comparing theoretical rankings with actual execution rankings; and (3) Capability-Aligned Planning Optimization (CAPO), which guides the planner to generate subtasks aligned with performance-aware strategies. Experimental comparisons against state-of-the-art methods demonstrate PerfGuard's advantages in tool selection accuracy, execution reliability, and alignment with user intent, validating its robustness and practical utility for complex AIGC tasks. The project code is available at https://github.com/FelixChan9527/PerfGuard.

  • 8 authors
·
Jan 30

AgentNet: Decentralized Evolutionary Coordination for LLM-based Multi-Agent Systems

The rapid advancement of large language models (LLMs) has enabled the development of multi-agent systems where multiple LLM-based agents collaborate on complex tasks. However, existing systems often rely on centralized coordination, leading to scalability bottlenecks, reduced adaptability, and single points of failure. Privacy and proprietary knowledge concerns further hinder cross-organizational collaboration, resulting in siloed expertise. We propose AgentNet, a decentralized, Retrieval-Augmented Generation (RAG)-based framework that enables LLM-based agents to specialize, evolve, and collaborate autonomously in a dynamically structured Directed Acyclic Graph (DAG). Unlike prior approaches with static roles or centralized control, AgentNet allows agents to adjust connectivity and route tasks based on local expertise and context. AgentNet introduces three key innovations: (1) a fully decentralized coordination mechanism that eliminates the need for a central orchestrator, enhancing robustness and emergent intelligence; (2) dynamic agent graph topology that adapts in real time to task demands, ensuring scalability and resilience; and (3) a retrieval-based memory system for agents that supports continual skill refinement and specialization. By minimizing centralized control and data exchange, AgentNet enables fault-tolerant, privacy-preserving collaboration across organizations. Experiments show that AgentNet achieves higher task accuracy than both single-agent and centralized multi-agent baselines.

  • 7 authors
·
Apr 1, 2025

Training-free CryoET Tomogram Segmentation

Cryogenic Electron Tomography (CryoET) is a useful imaging technology in structural biology that is hindered by its need for manual annotations, especially in particle picking. Recent works have endeavored to remedy this issue with few-shot learning or contrastive learning techniques. However, supervised training is still inevitable for them. We instead choose to leverage the power of existing 2D foundation models and present a novel, training-free framework, CryoSAM. In addition to prompt-based single-particle instance segmentation, our approach can automatically search for similar features, facilitating full tomogram semantic segmentation with only one prompt. CryoSAM is composed of two major parts: 1) a prompt-based 3D segmentation system that uses prompts to complete single-particle instance segmentation recursively with Cross-Plane Self-Prompting, and 2) a Hierarchical Feature Matching mechanism that efficiently matches relevant features with extracted tomogram features. They collaborate to enable the segmentation of all particles of one category with just one particle-specific prompt. Our experiments show that CryoSAM outperforms existing works by a significant margin and requires even fewer annotations in particle picking. Further visualizations demonstrate its ability when dealing with full tomogram segmentation for various subcellular structures. Our code is available at: https://github.com/xulabs/aitom

  • 8 authors
·
Jul 7, 2024

OSUM-EChat: Enhancing End-to-End Empathetic Spoken Chatbot via Understanding-Driven Spoken Dialogue

Empathy is crucial in enabling natural interactions within spoken dialogue systems, allowing machines to recognize and respond appropriately to paralinguistic cues such as age, gender, and emotion. Recent advancements in end-to-end speech language models, which unify speech understanding and generation, provide promising solutions. However, several challenges persist, including an over-reliance on large-scale dialogue datasets, insufficient extraction of paralinguistic cues vital for conveying empathy, and the lack of empathy-specific datasets and evaluation frameworks. To address these issues, we introduce OSUM-EChat, an open-source, end-to-end spoken dialogue system designed to enhance empathetic interactions, particularly in resource-limited settings. OSUM-EChat introduces two key innovations: (1) a three-stage understanding-driven spoken dialogue training strategy that extends the capabilities of a large speech understanding model to spoken dialogue tasks, and (2) a linguistic-paralinguistic dual thinking mechanism that integrates paralinguistic understanding through a chain of thought with dialogue generation, enabling the system to produce more empathetic responses. This approach reduces reliance on large-scale dialogue datasets while maintaining high-quality empathetic interactions. Additionally, we introduce the EChat-200K dataset, a rich corpus of empathetic speech-to-speech dialogues, and the EChat-eval benchmark, a comprehensive framework for evaluating the empathetic capabilities of dialogue systems. Experimental results demonstrate that OSUM-EChat outperforms end-to-end spoken dialogue models regarding empathetic responsiveness, validating its effectiveness.

  • 23 authors
·
Aug 13, 2025

WarmServe: Enabling One-for-Many GPU Prewarming for Multi-LLM Serving

Deploying multiple models within shared GPU clusters is a key strategy to improve resource efficiency in large language model (LLM) serving. Existing multi-LLM serving systems improve GPU utilization at the cost of degraded inference performance, particularly time-to-first-token (TTFT). We attribute this degradation to the lack of awareness regarding future workload characteristics. In contrast, recent analyses have shown the strong periodicity and long-term predictability of real-world LLM serving workloads. In this paper, we propose one-for-many GPU prewarming, which proactively loads parameters from multiple models onto GPUs based on workload forecasts. These prewarmed weights enable the system to promptly instantiate serving instances upon encountering request bursts. We design and implement WarmServe, a multi-LLM serving system incorporating three key techniques: (1) a model placement algorithm that optimizes prewarming decisions to minimize cross-model prewarming interference, (2) a KV cache reservation strategy that repurposes idle KV cache space on running GPUs for prewarming new models, and (3) an efficient GPU memory switching mechanism for tensor management. Evaluation on real-world datasets shows that WarmServe reduces tail TTFT by up to 50.8times compared to the state-of-the-art autoscaling-based system, while supporting up to 2.5times higher request throughput than the GPU-sharing system.

  • 8 authors
·
May 20

ETA: Efficiency through Thinking Ahead, A Dual Approach to Self-Driving with Large Models

How can we benefit from large models without sacrificing inference speed, a common dilemma in self-driving systems? A prevalent solution is a dual-system architecture, employing a small model for rapid, reactive decisions and a larger model for slower but more informative analyses. Existing dual-system designs often implement parallel architectures where inference is either directly conducted using the large model at each current frame or retrieved from previously stored inference results. However, these works still struggle to enable large models for a timely response to every online frame. Our key insight is to shift intensive computations of the current frame to previous time steps and perform a batch inference of multiple time steps to make large models respond promptly to each time step. To achieve the shifting, we introduce Efficiency through Thinking Ahead (ETA), an asynchronous system designed to: (1) propagate informative features from the past to the current frame using future predictions from the large model, (2) extract current frame features using a small model for real-time responsiveness, and (3) integrate these dual features via an action mask mechanism that emphasizes action-critical image regions. Evaluated on the Bench2Drive CARLA Leaderboard-v2 benchmark, ETA advances state-of-the-art performance by 8% with a driving score of 69.53 while maintaining a near-real-time inference speed at 50 ms.

  • 5 authors
·
Jun 8, 2025

A Survey on LLM-powered Agents for Recommender Systems

Recommender systems are essential components of many online platforms, yet traditional approaches still struggle with understanding complex user preferences and providing explainable recommendations. The emergence of Large Language Model (LLM)-powered agents offers a promising approach by enabling natural language interactions and interpretable reasoning, potentially transforming research in recommender systems. This survey provides a systematic review of the emerging applications of LLM-powered agents in recommender systems. We identify and analyze three key paradigms in current research: (1) Recommender-oriented approaches, which leverage intelligent agents to enhance the fundamental recommendation mechanisms; (2) Interaction-oriented approaches, which facilitate dynamic user engagement through natural dialogue and interpretable suggestions; and (3) Simulation-oriented approaches, which employ multi-agent frameworks to model complex user-item interactions and system dynamics. Beyond paradigm categorization, we analyze the architectural foundations of LLM-powered recommendation agents, examining their essential components: profile construction, memory management, strategic planning, and action execution. Our investigation extends to a comprehensive analysis of benchmark datasets and evaluation frameworks in this domain. This systematic examination not only illuminates the current state of LLM-powered agent recommender systems but also charts critical challenges and promising research directions in this transformative field.

  • 5 authors
·
Feb 14, 2025

A Survey on (M)LLM-Based GUI Agents

Graphical User Interface (GUI) Agents have emerged as a transformative paradigm in human-computer interaction, evolving from rule-based automation scripts to sophisticated AI-driven systems capable of understanding and executing complex interface operations. This survey provides a comprehensive examination of the rapidly advancing field of LLM-based GUI Agents, systematically analyzing their architectural foundations, technical components, and evaluation methodologies. We identify and analyze four fundamental components that constitute modern GUI Agents: (1) perception systems that integrate text-based parsing with multimodal understanding for comprehensive interface comprehension; (2) exploration mechanisms that construct and maintain knowledge bases through internal modeling, historical experience, and external information retrieval; (3) planning frameworks that leverage advanced reasoning methodologies for task decomposition and execution; and (4) interaction systems that manage action generation with robust safety controls. Through rigorous analysis of these components, we reveal how recent advances in large language models and multimodal learning have revolutionized GUI automation across desktop, mobile, and web platforms. We critically examine current evaluation frameworks, highlighting methodological limitations in existing benchmarks while proposing directions for standardization. This survey also identifies key technical challenges, including accurate element localization, effective knowledge retrieval, long-horizon planning, and safety-aware execution control, while outlining promising research directions for enhancing GUI Agents' capabilities. Our systematic review provides researchers and practitioners with a thorough understanding of the field's current state and offers insights into future developments in intelligent interface automation.

  • 15 authors
·
Mar 27, 2025

RGA-Net: A Vision Enhancement Framework for Robotic Surgical Systems Using Reciprocal Attention Mechanisms

Robotic surgical systems rely heavily on high-quality visual feedback for precise teleoperation; yet, surgical smoke from energy-based devices significantly degrades endoscopic video feeds, compromising the human-robot interface and surgical outcomes. This paper presents RGA-Net (Reciprocal Gating and Attention-fusion Network), a novel deep learning framework specifically designed for smoke removal in robotic surgery workflows. Our approach addresses the unique challenges of surgical smoke-including dense, non-homogeneous distribution and complex light scattering-through a hierarchical encoder-decoder architecture featuring two key innovations: (1) a Dual-Stream Hybrid Attention (DHA) module that combines shifted window attention with frequency-domain processing to capture both local surgical details and global illumination changes, and (2) an Axis-Decomposed Attention (ADA) module that efficiently processes multi-scale features through factorized attention mechanisms. These components are connected via reciprocal cross-gating blocks that enable bidirectional feature modulation between encoder and decoder pathways. Extensive experiments on the DesmokeData and LSD3K surgical datasets demonstrate that RGA-Net achieves superior performance in restoring visual clarity suitable for robotic surgery integration. Our method enhances the surgeon-robot interface by providing consistently clear visualization, laying a technical foundation for alleviating surgeons' cognitive burden, optimizing operation workflows, and reducing iatrogenic injury risks in minimally invasive procedures. These practical benefits could be further validated through future clinical trials involving surgeon usability assessments. The proposed framework represents a significant step toward more reliable and safer robotic surgical systems through computational vision enhancement.

  • 6 authors
·
Feb 14

PersonalAI 2.0: Enhancing knowledge graph traversal/retrieval with planning mechanism for Personalized LLM Agents

We introduce PersonalAI 2.0 (PAI-2), a novel framework, designed to enhance large language model (LLM) based systems through integration of external knowledge graphs (KG). The proposed approach addresses key limitations of existing Graph Retrieval-Augmented Generation (GraphRAG) methods by incorporating a dynamic, multistage query processing pipeline. The central point of PAI-2 design is its ability to perform adaptive, iterative information search, guided by extracted entities, matched graph vertices and generated clue-queries. Conducted evaluation over six benchmarks (Natural Questions, TriviaQA, HotpotQA, 2WikiMultihopQA, MuSiQue and DiaASQ) demonstrates improvement in factual correctness of generating answers compared to analogues methods (LightRAG, RAPTOR, and HippoRAG 2). PAI-2 achieves 4% average gain by LLM-as-a-Judge across four benchmarks, reflecting its effectiveness in reducing hallucination rates and increasing precision. We show that use of graph traversal algorithms (e.g. BeamSearch, WaterCircles) gain superior results compared to standard flatten retriever on average 6%, while enabled search plan enhancement mechanism gain 18% boost compared to disabled one by LLM-as-a-Judge across six datasets. In addition, ablation study reveals that PAI-2 achieves the SOTA result on MINE-1 benchmark, achieving 89% information-retention score, using LLMs from 7-14B tiers. Collectively, these findings underscore the potential of PAI-2 to serve as a foundational model for next-generation personalized AI applications, requiring scalable, context-aware knowledge representation and reasoning capabilities.

s-nlp s-nlp
·
May 12 2

Empowering Agentic Video Analytics Systems with Video Language Models

AI-driven video analytics has become increasingly pivotal across diverse domains. However, existing systems are often constrained to specific, predefined tasks, limiting their adaptability in open-ended analytical scenarios. The recent emergence of Video-Language Models (VLMs) as transformative technologies offers significant potential for enabling open-ended video understanding, reasoning, and analytics. Nevertheless, their limited context windows present challenges when processing ultra-long video content, which is prevalent in real-world applications. To address this, we introduce AVAS, a VLM-powered system designed for open-ended, advanced video analytics. AVAS incorporates two key innovations: (1) the near real-time construction of Event Knowledge Graphs (EKGs) for efficient indexing of long or continuous video streams, and (2) an agentic retrieval-generation mechanism that leverages EKGs to handle complex and diverse queries. Comprehensive evaluations on public benchmarks, LVBench and VideoMME-Long, demonstrate that AVAS achieves state-of-the-art performance, attaining 62.3% and 64.1% accuracy, respectively, significantly surpassing existing VLM and video Retrieval-Augmented Generation (RAG) systems. Furthermore, to evaluate video analytics in ultra-long and open-world video scenarios, we introduce a new benchmark, AVAS-100. This benchmark comprises 8 videos, each exceeding 10 hours in duration, along with 120 manually annotated, diverse, and complex question-answer pairs. On AVAS-100, AVAS achieves top-tier performance with an accuracy of 75.8%.

  • 8 authors
·
Apr 30, 2025

UniMS-RAG: A Unified Multi-source Retrieval-Augmented Generation for Personalized Dialogue Systems

Large Language Models (LLMs) has shown exceptional capabilities in many natual language understanding and generation tasks. However, the personalization issue still remains a much-coveted property, especially when it comes to the multiple sources involved in the dialogue system. To better plan and incorporate the use of multiple sources in generating personalized response, we firstly decompose it into three sub-tasks: Knowledge Source Selection, Knowledge Retrieval, and Response Generation. We then propose a novel Unified Multi-Source Retrieval-Augmented Generation system (UniMS-RAG) Specifically, we unify these three sub-tasks with different formulations into the same sequence-to-sequence paradigm during the training, to adaptively retrieve evidences and evaluate the relevance on-demand using special tokens, called acting tokens and evaluation tokens. Enabling language models to generate acting tokens facilitates interaction with various knowledge sources, allowing them to adapt their behavior to diverse task requirements. Meanwhile, evaluation tokens gauge the relevance score between the dialogue context and the retrieved evidence. In addition, we carefully design a self-refinement mechanism to iteratively refine the generated response considering 1) the consistency scores between the generated response and retrieved evidence; and 2) the relevance scores. Experiments on two personalized datasets (DuLeMon and KBP) show that UniMS-RAG achieves state-of-the-art performance on the knowledge source selection and response generation task with itself as a retriever in a unified manner. Extensive analyses and discussions are provided for shedding some new perspectives for personalized dialogue systems.

  • 9 authors
·
Jan 24, 2024

G-Memory: Tracing Hierarchical Memory for Multi-Agent Systems

Large language model (LLM)-powered multi-agent systems (MAS) have demonstrated cognitive and execution capabilities that far exceed those of single LLM agents, yet their capacity for self-evolution remains hampered by underdeveloped memory architectures. Upon close inspection, we are alarmed to discover that prevailing MAS memory mechanisms (1) are overly simplistic, completely disregarding the nuanced inter-agent collaboration trajectories, and (2) lack cross-trial and agent-specific customization, in stark contrast to the expressive memory developed for single agents. To bridge this gap, we introduce G-Memory, a hierarchical, agentic memory system for MAS inspired by organizational memory theory, which manages the lengthy MAS interaction via a three-tier graph hierarchy: insight, query, and interaction graphs. Upon receiving a new user query, G-Memory performs bi-directional memory traversal to retrieve both high-level, generalizable insights that enable the system to leverage cross-trial knowledge, and fine-grained, condensed interaction trajectories that compactly encode prior collaboration experiences. Upon task execution, the entire hierarchy evolves by assimilating new collaborative trajectories, nurturing the progressive evolution of agent teams. Extensive experiments across five benchmarks, three LLM backbones, and three popular MAS frameworks demonstrate that G-Memory improves success rates in embodied action and accuracy in knowledge QA by up to 20.89% and 10.12%, respectively, without any modifications to the original frameworks. Our codes are available at https://github.com/bingreeky/GMemory.

  • 6 authors
·
Jun 8, 2025

LDP: An Identity-Aware Protocol for Multi-Agent LLM Systems

As multi-agent AI systems grow in complexity, the protocols connecting them constrain their capabilities. Current protocols such as A2A and MCP do not expose model-level properties as first-class primitives, ignoring properties fundamental to effective delegation: model identity, reasoning profile, quality calibration, and cost characteristics. We present the LLM Delegate Protocol (LDP), an AI-native communication protocol introducing five mechanisms: (1) rich delegate identity cards with quality hints and reasoning profiles; (2) progressive payload modes with negotiation and fallback; (3) governed sessions with persistent context; (4) structured provenance tracking confidence and verification status; (5) trust domains enforcing security boundaries at the protocol level. We implement LDP as a plugin for the JamJet agent runtime and evaluate against A2A and random baselines using local Ollama models and LLM-as-judge evaluation. Identity-aware routing achieves ~12x lower latency on easy tasks through delegate specialization, though it does not improve aggregate quality in our small delegate pool; semantic frame payloads reduce token count by 37% (p=0.031) with no observed quality loss; governed sessions eliminate 39% token overhead at 10 rounds; and noisy provenance degrades synthesis quality below the no-provenance baseline, arguing that confidence metadata is harmful without verification. Simulated analyses show architectural advantages in attack detection (96% vs. 6%) and failure recovery (100% vs. 35% completion). This paper contributes a protocol design, reference implementation, and initial evidence that AI-native protocol primitives enable more efficient and governable delegation.

  • 1 authors
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Mar 8

Silent Leaks: Implicit Knowledge Extraction Attack on RAG Systems through Benign Queries

Retrieval-Augmented Generation (RAG) systems enhance large language models (LLMs) by incorporating external knowledge bases, but this may expose them to extraction attacks, leading to potential copyright and privacy risks. However, existing extraction methods typically rely on malicious inputs such as prompt injection or jailbreaking, making them easily detectable via input- or output-level detection. In this paper, we introduce Implicit Knowledge Extraction Attack (IKEA), which conducts Knowledge Extraction on RAG systems through benign queries. Specifically, IKEA first leverages anchor concepts-keywords related to internal knowledge-to generate queries with a natural appearance, and then designs two mechanisms that lead anchor concepts to thoroughly "explore" the RAG's knowledge: (1) Experience Reflection Sampling, which samples anchor concepts based on past query-response histories, ensuring their relevance to the topic; (2) Trust Region Directed Mutation, which iteratively mutates anchor concepts under similarity constraints to further exploit the embedding space. Extensive experiments demonstrate IKEA's effectiveness under various defenses, surpassing baselines by over 80% in extraction efficiency and 90% in attack success rate. Moreover, the substitute RAG system built from IKEA's extractions shows comparable performance to the original RAG and outperforms those based on baselines across multiple evaluation tasks, underscoring the stealthy copyright infringement risk in RAG systems.

  • 8 authors
·
May 21, 2025

One Sentence, One Drama: Personalized Short-Form Drama Generation via Multi-Agent Systems

Existing approaches for digital short-drama production typically rely on one-shot LLM generated scripts and loosely coupled pipelines, which fail to satisfy three key requirements of short-drama generation: (1) narrative pacing, resulting in weak hooks, insufficient escalation, and unattractive endings; (2) spatial consistency, leading to drifting scene layouts and inconsistent character positions across clips; and (3) production-level quality control, requiring extensive manual review and correction across script and visual stages. We present One Sentence, One Drama, a hierarchical multi-agent framework that transforms a user's single-sentence idea into a fully produced short drama through structured intermediate modules and iterative refinement. Our approach is built upon three key components: (1) a multi-agent debate-based story generation module that enforces short-drama pacing and narrative coherence; (2) a 3D-grounded first-frame generation mechanism that establishes a shared spatial reference for consistent character positioning and scene layout across clips; and (3) multi-stage reviewer loops that perform comprehensive error detection and targeted revision across script, visual, and video generation stages. We also introduce scene-level BGM matching and scene transition planning to improve the audience's immersive experience. To systematically evaluate this task, we introduce Short-Drama-Bench, a benchmark that extends standard video quality metrics with short-drama-specific criteria. Experimental results demonstrate that our method significantly outperforms existing pipelines in narrative quality, cross-clip consistency, and overall viewing experience.

LLMs Cannot Reliably Judge (Yet?): A Comprehensive Assessment on the Robustness of LLM-as-a-Judge

Large Language Models (LLMs) have demonstrated exceptional capabilities across diverse tasks, driving the development and widespread adoption of LLM-as-a-Judge systems for automated evaluation, including red teaming and benchmarking. However, these systems are susceptible to adversarial attacks that can manipulate evaluation outcomes, raising critical concerns about their robustness and trustworthiness. Existing evaluation methods for LLM-based judges are often fragmented and lack a unified framework for comprehensive robustness assessment. Furthermore, the impact of prompt template design and model selection on judge robustness has rarely been explored, and their performance in real-world deployments remains largely unverified. To address these gaps, we introduce RobustJudge, a fully automated and scalable framework designed to systematically evaluate the robustness of LLM-as-a-Judge systems. Specifically, RobustJudge investigates the effectiveness of 15 attack methods and 7 defense strategies across 12 models (RQ1), examines the impact of prompt template design and model selection (RQ2), and evaluates the security of real-world deployments (RQ3). Our study yields three key findings: (1) LLM-as-a-Judge systems are highly vulnerable to attacks such as PAIR and combined attacks, while defense mechanisms such as re-tokenization and LLM-based detectors can provide enhanced protection; (2) robustness varies substantially across prompt templates (up to 40%); (3) deploying RobustJudge on Alibaba's PAI platform uncovers previously undiscovered vulnerabilities. These results offer practical insights for building trustworthy LLM-as-a-Judge systems.

  • 9 authors
·
Nov 15, 2025

Who Audits the Auditors? Recommendations from a field scan of the algorithmic auditing ecosystem

AI audits are an increasingly popular mechanism for algorithmic accountability; however, they remain poorly defined. Without a clear understanding of audit practices, let alone widely used standards or regulatory guidance, claims that an AI product or system has been audited, whether by first-, second-, or third-party auditors, are difficult to verify and may exacerbate, rather than mitigate, bias and harm. To address this knowledge gap, we provide the first comprehensive field scan of the AI audit ecosystem. We share a catalog of individuals (N=438) and organizations (N=189) who engage in algorithmic audits or whose work is directly relevant to algorithmic audits; conduct an anonymous survey of the group (N=152); and interview industry leaders (N=10). We identify emerging best practices as well as methods and tools that are becoming commonplace, and enumerate common barriers to leveraging algorithmic audits as effective accountability mechanisms. We outline policy recommendations to improve the quality and impact of these audits, and highlight proposals with wide support from algorithmic auditors as well as areas of debate. Our recommendations have implications for lawmakers, regulators, internal company policymakers, and standards-setting bodies, as well as for auditors. They are: 1) require the owners and operators of AI systems to engage in independent algorithmic audits against clearly defined standards; 2) notify individuals when they are subject to algorithmic decision-making systems; 3) mandate disclosure of key components of audit findings for peer review; 4) consider real-world harm in the audit process, including through standardized harm incident reporting and response mechanisms; 5) directly involve the stakeholders most likely to be harmed by AI systems in the algorithmic audit process; and 6) formalize evaluation and, potentially, accreditation of algorithmic auditors.

  • 5 authors
·
Oct 3, 2023

Model of Models: When Does Emitting a Specialist Beat Attending, Adapting, or Tuning?

Given a task described by a few examples, how should a model be specialized to it? Four mechanisms are available -- zero-shot, in-context attention, test-time gradient adaptation, and emitting specialist weights from a hypernetwork -- yet the operating regime of the last is rarely mapped. We run the identical four-way comparison across six tasks spanning regression, generation, language modeling, reinforcement learning, and clinical and genomic classification, holding the specialist, the context, and (where we can) the training budget fixed. The clearest wins for emission are about cost at matched quality: it ties the state-of-the-art amortized tabular model (TabPFN) on clinical few-shot classification while emitting a reusable specialist instead of re-attending the support set per query, and reaches noise-floor shape generation with a 132-float per-instance program. On few-shot sinusoid regression it is 2--3 orders of magnitude below MAML at zero test-time gradient steps -- a margin that narrows to sim30times but persists once training budgets are equalized. Emission cannot match in-context attention on high-dimensional sequence modeling: under matched-budget pre-training a one-pass adapter recovers only a minority of the in-context gain (14.0pm0.9% at 5M, 11.2pm0.5% at 15M), and a LoRA-rank sweep shows this shortfall is a partial capacity limit -- capture climbs from 5% to 21% as rank grows but plateaus far below full recovery. Mechanism ablations confirm the emitted specialist is genuinely task-conditioned, not a memorized prior; and, more speculatively, emitted specialists compose in weight space -- interpolating two of them tracks the corresponding blend of their functions. We close with a falsifiable thesis, operationalized through a per-task resolution measure, bounding when each conditioning mechanism should be preferred.

  • 1 authors
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Jul 19

Pep2Prob Benchmark: Predicting Fragment Ion Probability for MS^2-based Proteomics

Proteins perform nearly all cellular functions and constitute most drug targets, making their analysis fundamental to understanding human biology in health and disease. Tandem mass spectrometry (MS^2) is the major analytical technique in proteomics that identifies peptides by ionizing them, fragmenting them, and using the resulting mass spectra to identify and quantify proteins in biological samples. In MS^2 analysis, peptide fragment ion probability prediction plays a critical role, enhancing the accuracy of peptide identification from mass spectra as a complement to the intensity information. Current approaches rely on global statistics of fragmentation, which assumes that a fragment's probability is uniform across all peptides. Nevertheless, this assumption is oversimplified from a biochemical principle point of view and limits accurate prediction. To address this gap, we present Pep2Prob, the first comprehensive dataset and benchmark designed for peptide-specific fragment ion probability prediction. The proposed dataset contains fragment ion probability statistics for 608,780 unique precursors (each precursor is a pair of peptide sequence and charge state), summarized from more than 183 million high-quality, high-resolution, HCD MS^2 spectra with validated peptide assignments and fragmentation annotations. We establish baseline performance using simple statistical rules and learning-based methods, and find that models leveraging peptide-specific information significantly outperform previous methods using only global fragmentation statistics. Furthermore, performance across benchmark models with increasing capacities suggests that the peptide-fragmentation relationship exhibits complex nonlinearities requiring sophisticated machine learning approaches.

  • 5 authors
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Aug 12, 2025

Retrofitting Recurrent Depth into a Pretrained Language Model: Installation, Extrapolation, Transfer, and Retention at Two Parameter Budgets

A dense, pretrained language model can be retrofitted with recurrent depth and learn an iterative latent transition that persists after outcome-only annealing. Qwen2.5-0.5B-Instruct is split into a Prelude, a weight-tied Recurrent Block, and a Coda, with an identity-preserving one-loop path and a re-entry bridge on later loops. At loop 1 the retrofit remains non-inferior to its base on a preregistered ARC battery. Three findings. First, the mechanism is a reusable procedure rather than terminal-answer lookup, and installs at two budgets: 6M trained parameters over frozen base weights and 180M full-block. With intermediate-step supervision, the model computes one task step per loop and persists when only final answers are graded. The adapter matched the full block overall (83.8% versus 84.0%), led through depth 11, and trailed beyond. Verbal fine-tuning reached 79-86% on controlled verbal renderings (zero-shot transfer was minimal), and adapter verbal training begun from the installed mechanism outpaced matched fresh training by 18.6 points, including on a held-out test set. Second, the operation extrapolates to roughly 1.5 times its supervised depth, holding 70% accuracy through depth 18. Third, a same-size scratchpad-trained model matched the recurrent model within its learned horizon but collapsed beyond it. The recurrent model won overall, 84% versus 72%, retained 53% versus 2.5% beyond depth 10, and answered 7.6 times faster. An iterative transformer can therefore perform deeper reasoning in latent space faster than comparable or larger models fine-tuned on the same task, in a system-level comparison. A second task, running the rule in reverse, exposed the limits: the inverse was learnable in isolation, but no continuation acquired it while preserving the installed mechanism and general capability, a catastrophic-interference boundary. Learned depth selection remains open.

  • 1 authors
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Jul 30

sudo rm -rf agentic_security

Large Language Models (LLMs) are increasingly deployed as computer-use agents, autonomously performing tasks within real desktop or web environments. While this evolution greatly expands practical use cases for humans, it also creates serious security exposures. We present SUDO (Screen-based Universal Detox2Tox Offense), a novel attack framework that systematically bypasses refusal-trained safeguards in commercial computer-use agents, such as Claude for Computer Use. The core mechanism, Detox2Tox, transforms harmful requests (that agents initially reject) into seemingly benign requests via detoxification, secures detailed instructions from advanced vision language models (VLMs), and then reintroduces malicious content via toxification just before execution. Unlike conventional jailbreaks, SUDO iteratively refines its attacks based on a built-in refusal feedback, making it increasingly effective against robust policy filters. In extensive tests spanning 50 real-world tasks and multiple state-of-the-art VLMs, SUDO achieves a stark attack success rate of 24.41% (with no refinement), and up to 41.33% (by its iterative refinement) in Claude for Computer Use. By revealing these vulnerabilities and demonstrating the ease with which they can be exploited in real-world computing environments, this paper highlights an immediate need for robust, context-aware safeguards. WARNING: This paper includes harmful or offensive model outputs

AIM-Intelligence AIM Intelligence
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Mar 26, 2025

Dualformer: Controllable Fast and Slow Thinking by Learning with Randomized Reasoning Traces

In human cognition theory, human thinking is governed by two systems: the fast and intuitive System 1 and the slower but more deliberative System 2. Recent studies have shown that incorporating System 2 process into Transformers including large language models (LLMs), significantly enhances their reasoning capabilities. Nevertheless, models that purely resemble System 2 thinking require substantially higher computational costs and are much slower to respond. To address this challenge, we present Dualformer, a single Transformer model that seamlessly integrates both the fast and slow reasoning modes. Dualformer is obtained by training on data with randomized reasoning traces, where different parts of the traces are dropped during training. The dropping strategies are specifically tailored according to the trace structure, analogous to analyzing our thinking process and creating shortcuts with patterns. At inference time, our model can be configured to output only the solutions (fast mode) or both the reasoning chain and the final solution (slow mode), or automatically decide which mode to engage (auto mode). In all cases, Dualformer outperforms the corresponding baseline models in both performance and computational efficiency: (1) in slow mode, Dualformer optimally solves unseen 30 x 30 maze navigation tasks 97.6% of the time, surpassing the Searchformer (trained on data with complete reasoning traces) baseline performance of 93.3%, while only using 45.5% fewer reasoning steps; (2) in fast mode, Dualformer completes those tasks with an 80% optimal rate, significantly outperforming the Solution-Only model (trained on solution-only data), which has an optimal rate of only 30%. For math problems, our techniques have also achieved improved performance with LLM fine-tuning, showing its generalization beyond task-specific models.

  • 5 authors
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Oct 13, 2024

Learning to Chain Operations by Routing Information Through a Global Workspace

We present a model inspired by the Global Workspace Theory that integrates specialized modules to perform a sequential reasoning task. A controller selectively routes information between modules through the workspace using a gating mechanism. This approach allows the model to chain operations by iteratively broadcasting information between specialized domains, mimicking System-2 reasoning. We evaluate the model's performance on a simple addition task, where two addends must be summed. The task can be solved by routing information sequentially through an Input module, an Increment module (multiple times), and finally an Output module. We consider two implementations of this system with increasing complexity. First, using hand-designed modules operating on one-hot digit representations, the controller (a LSTM recurrent network) learns to select the appropriate modules (input, increment, output) in the appropriate sequence. Second, we replace the hand-designed modules with learned representation modules for MNIST images and an increment module trained on the task objectives; here again, the controller learns the appropriate sequential module selection to solve the task. Finally, we show that the Global Workspace model, while having fewer parameters, outperforms LSTMs and Transformers when tested on unseen addition operations (both interpolations and extrapolations of addition operations seen during training). Our results highlight the potential of architectures inspired by the Global Workspace Theory to enhance deep learning's reasoning capabilities.

  • 2 authors
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Feb 28, 2025

Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies

There is a widening recognition that cancer cells are products of complex developmental processes. Carcinogenesis and metastasis formation are increasingly described as systems-level, network phenomena. Here we propose that malignant transformation is a two-phase process, where an initial increase of system plasticity is followed by a decrease of plasticity at late stages of carcinogenesis as a model of cellular learning. We describe the hallmarks of increased system plasticity of early, tumor initiating cells, such as increased noise, entropy, conformational and phenotypic plasticity, physical deformability, cell heterogeneity and network rearrangements. Finally, we argue that the large structural changes of molecular networks during cancer development necessitate a rather different targeting strategy in early and late phase of carcinogenesis. Plastic networks of early phase cancer development need a central hit, while rigid networks of late stage primary tumors or established metastases should be attacked by the network influence strategy, such as by edgetic, multi-target, or allo-network drugs. Cancer stem cells need special diagnosis and targeting, since their dormant and rapidly proliferating forms may have more rigid, or more plastic networks, respectively. The extremely high ability to change their rigidity/plasticity may be a key differentiating hallmark of cancer stem cells. The application of early stage-optimized anti-cancer drugs to late-stage patients may be a reason of many failures in anti-cancer therapies. Our hypotheses presented here underlie the need for patient-specific multi-target therapies applying the correct ratio of central hits and network influences -- in an optimized sequence.

  • 6 authors
·
Jun 14, 2013

Mechanist: AI as a Scientific Instrument for Discovering the Mechanisms of Intelligence

AI models have achieved remarkable success across diverse domains, yet the mechanisms underlying their capabilities and the risks they may pose remain poorly understood. As AI development becomes faster and increasingly automated, mechanistic exploration remains largely manual, widening the gap between what models can do and our ability to understand and control them. To bridge this gap, we introduce Mechanist, an agentic system that uses AI as a scientific instrument for the autonomous discovery of mechanisms underlying AI intelligence. To support autonomous mechanistic discovery, we construct an interpretability-focused knowledge graph of approximately 13,000 papers and integrate it with a multidisciplinary database of 43 million papers spanning 26 fields. We further curate a library of 32 foundational methods for mechanism analysis, causal intervention, and validation. Compared with Claude Code and existing AI-scientist systems, Mechanist generates more valuable mechanism hypotheses and executes experiments more reliably. Mechanist also demonstrates a progression from discovering model behaviors to explaining and controlling AI models. Specifically, Mechanist first uncovers a counterintuitive safety risk in scientific laboratories, showing that unsafe traits can transfer across modalities through apparently safe training data. Mechanist then develops a mechanism theory of belief, revealing how models represent world knowledge, form beliefs, infer the beliefs of others, and how these mechanisms emerge during pretraining. Finally, Mechanist translates these mechanistic insights into practical interventions that improve model performance across diverse scenarios and steer scientific foundation models toward generating DNA sequences with specified properties.

zjunlp ZJUNLP
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Aug 11 2